Getting off Effexor EEEEEk!

topic posted Tue, May 10, 2005 - 9:56 AM by  jimgandhi
That is right, I must endure the hell that is getting off effexor. I just think Welbutrin deserves a try. Hopefully less side effect. Effexor just doesnt work with my lifestyle, aside from helping me not feel like I want to kill myself...lol
When I drink on effexor I tend to black out then go into a deep deep depression the next day as though the alcohol leeched all the neuro chemicals away. My sex drive have been shitty as well. If my girlfriend isnt boning someone else, I dont know how she deals with it..
Its funny though, effexor and pot do not cause me any problems just that damn alcohol. Its coming off effexor and getting back on welbutrin that is going to be a motherfucker, just an emotional rollercoaster! Would be more than willing to take anyones advice on how to do this.
posted by:
jimgandhi
Seattle
  • Re: Getting off Effexor EEEEEk!

    Wed, April 4, 2007 - 6:25 PM
    I'm reading this almost 2 years later, but I'm curious to see how you are doing? I was on Effexor for years, a few years ago and I had a hellish time coming off of it. In fact, I was not able to. I'm in the healthcare profession, so I have access to journal articles and such, so I did my own research. I found a hot-off-the-press journal article examining the so called "discontinuation syndrome." Why don't they just call it what it really is: withdrawal? Anyhow, this article noted 5 or so case studies of research done by a psychiatrist and he noted that because Effexor and Paxil have such short half-lives, they they are more likely to cause the "withdrawal." So while tapering the Effexor, he replaced it with a 5 day course of Prozac as its half-life is much longer and this managed to decrease and/or prevent the withdrawal in his patients.

    Anyhow, I brought the article to my doctor and she prescribed me a 5-day course and I was able to come off of Effexor and switch to Serzone with ZERO problems! She has used this with many other patients and has passed the info along to her colleagues. She often used to thank me and tell about all of the people she was able to help.

    Now the discontinuation syndrome is well documented (it was not even on the radar back then) and I believe many docs that know their pharmacotherapy use this approach as well as adding a benzodiazepine for 1 week during the transition.
    • Re: Getting off Effexor EEEEEk!

      Wed, March 26, 2008 - 4:34 AM
      Very true

      DO NOT SUDDENLY QUIT ANY SSNRI, SSRI or MAOI!

      Half life of various antidepressants

      Effexor and effexor XR 5 hours Typical onset of withdrawal Day 1 or 2

      Cymbalta half-life 12 hours Typical onset of withdrawal Day 1 or 2


      Antidepressant______halflife_______Frequency of withdrawal reactions

      Effexor____________5 hours_____________78%
      Paxil_____________21 hours_____________66%
      Zoloft____________26 hours_____________60%
      Prozac___________4-6 days_____________14%

      Source: “The Antidepressant Solution”
      by Joseph Glenmullen, M.D.

      Luvox half-life 15.6 hours Typical onset of withdrawal Day 2-3

      Serzone half-life 11 to 24 hours Typical onset of withdrawal Day 2-3

      Paxil CR half-life 21 hours Typical onset of withdrawal Day 2-3

      Paxil half-life 21 hours Typical onset of withdrawal Day 2-3

      Wellbutrin and Wellbutrin SR or XL half-life 21 hours Typical onset of withdrawal Day 2-3

      Zoloft half-life 26 hours Typical onset of withdrawal Day 3-4

      Lexapro half-life 27-32 hours Typical onset of withdrawal Day 3-5

      Remeron half-life 20-40 hours Typical onset of withdrawal Day 3-5

      Celexa half-life 35 hours Typical onset of withdrawal Day 3-6

      Prozac half-life 4 to 6 days Typical onset of withdrawal Day 2-3 weeks

      source “The Antidepressant Solution” By Joseph Glenmullen, M.D.