Getting off Effexor EEEEEk!

topic posted Tue, May 10, 2005 - 9:56 AM by  jimgandhi
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That is right, I must endure the hell that is getting off effexor. I just think Welbutrin deserves a try. Hopefully less side effect. Effexor just doesnt work with my lifestyle, aside from helping me not feel like I want to kill myself...lol
When I drink on effexor I tend to black out then go into a deep deep depression the next day as though the alcohol leeched all the neuro chemicals away. My sex drive have been shitty as well. If my girlfriend isnt boning someone else, I dont know how she deals with it..
Its funny though, effexor and pot do not cause me any problems just that damn alcohol. Its coming off effexor and getting back on welbutrin that is going to be a motherfucker, just an emotional rollercoaster! Would be more than willing to take anyones advice on how to do this.
posted by:
jimgandhi
Seattle
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  • Re: Getting off Effexor EEEEEk!

    Tue, October 10, 2006 - 12:20 AM
    Drinking on Effexor is a very bad idea. People have gotten them self's in big trouble doing that.
    • Re: Getting off Effexor EEEEEk!

      Wed, November 4, 2009 - 10:41 PM
      Drinking and Effexor

      SSRi's and Alcohol
      ________________________________________
      fiddaman.blogspot.com/2009/11...hol.html

      An interesting pdf file was sent to me from a fellow advocate last night. I only have the summary but it throws light on the subject of consuming alcohol whilst on SSRi's.

      The findings:

      from
      Abstracts of the 9th World Congress of Biological Psychiatry, Paris, June 2009

      P-10-004
      Violence as a side - effect of antidepressants: Provocation by alcohol
      David Menkes
      University of Auckland, Waikato Clinical School, Hamilton, New Zealand
      Andrew Herxheimer

      Objectives: Based on case-reports and epidemiological data, we reported the rare induction of serious violence by antidepressant treatment (PLoS Med 3(9): e372). Given alcohol’s prevalence and tendency to disinhibit behaviour, we studied its association with SSRI-induced violence.

      Methods: We analyzed some 200 cases drawn from our medicolegal practices, web-based patient discussion lists, and ADR reports to government authorities in Canada and the USA. Assessment was based on standard criteria for drug-effect causality (CIOMS), taking into account apparent sources of bias.

      Results: A distinct syndrome of uncharacteristic disinhibition with alcohol was detected in 40 individuals of either sex during treatment with SSRIs or venlafaxine. Outcomes included 12 homicides (2 of which were double), suicide, serious assault, unintended sexual intercourse, and other damaging or markedly embarrassing social behaviour. In the majority of cases, memory for the episode was lacking, often completely so. For most individuals, modest or usual amounts of alcohol were involved, with evidence that these had been well tolerated before antidepressant treatment,and after its discontinuation (challenge-dechallenge). In several cases, re-exposure to the same or related antidepressant reproduced the phenomenon (rechallenge).

      Conclusions: We identify a distinct and forensically important interaction between alcohol and SSRI antidepressants. Aggregated pharmacovigilance data (in preparation) corroborate the existence of this phenomenon. We suggest that antidepressant product warnings regarding alcohol, hitherto non-specific and unhelpful, will need to be reconsidered.

  • Re: Getting off Effexor EEEEEk!

    Wed, April 4, 2007 - 6:25 PM
    I'm reading this almost 2 years later, but I'm curious to see how you are doing? I was on Effexor for years, a few years ago and I had a hellish time coming off of it. In fact, I was not able to. I'm in the healthcare profession, so I have access to journal articles and such, so I did my own research. I found a hot-off-the-press journal article examining the so called "discontinuation syndrome." Why don't they just call it what it really is: withdrawal? Anyhow, this article noted 5 or so case studies of research done by a psychiatrist and he noted that because Effexor and Paxil have such short half-lives, they they are more likely to cause the "withdrawal." So while tapering the Effexor, he replaced it with a 5 day course of Prozac as its half-life is much longer and this managed to decrease and/or prevent the withdrawal in his patients.

    Anyhow, I brought the article to my doctor and she prescribed me a 5-day course and I was able to come off of Effexor and switch to Serzone with ZERO problems! She has used this with many other patients and has passed the info along to her colleagues. She often used to thank me and tell about all of the people she was able to help.

    Now the discontinuation syndrome is well documented (it was not even on the radar back then) and I believe many docs that know their pharmacotherapy use this approach as well as adding a benzodiazepine for 1 week during the transition.
    • Re: Getting off Effexor EEEEEk!

      Wed, March 26, 2008 - 4:34 AM
      Very true

      DO NOT SUDDENLY QUIT ANY SSNRI, SSRI or MAOI!

      Half life of various antidepressants

      Effexor and effexor XR 5 hours Typical onset of withdrawal Day 1 or 2

      Cymbalta half-life 12 hours Typical onset of withdrawal Day 1 or 2


      Antidepressant______halflife_______Frequency of withdrawal reactions

      Effexor____________5 hours_____________78%
      Paxil_____________21 hours_____________66%
      Zoloft____________26 hours_____________60%
      Prozac___________4-6 days_____________14%

      Source: “The Antidepressant Solution”
      by Joseph Glenmullen, M.D.

      Luvox half-life 15.6 hours Typical onset of withdrawal Day 2-3

      Serzone half-life 11 to 24 hours Typical onset of withdrawal Day 2-3

      Paxil CR half-life 21 hours Typical onset of withdrawal Day 2-3

      Paxil half-life 21 hours Typical onset of withdrawal Day 2-3

      Wellbutrin and Wellbutrin SR or XL half-life 21 hours Typical onset of withdrawal Day 2-3

      Zoloft half-life 26 hours Typical onset of withdrawal Day 3-4

      Lexapro half-life 27-32 hours Typical onset of withdrawal Day 3-5

      Remeron half-life 20-40 hours Typical onset of withdrawal Day 3-5

      Celexa half-life 35 hours Typical onset of withdrawal Day 3-6

      Prozac half-life 4 to 6 days Typical onset of withdrawal Day 2-3 weeks

      source “The Antidepressant Solution” By Joseph Glenmullen, M.D.
    • Re: Getting off Effexor EEEEEk!

      Wed, November 4, 2009 - 10:57 PM
      Serzone
      •Serzone (nefazodone), also properly an SNRI. The brand name Serzone has been withdrawn from use in the U.S. and several other countries due to the possibility of liver failure, but the generic nefazodone is still available.
      It is no longer available in Europe or Canada. I am always skeptical of a wonder drug don't think I would ever buy into any drug again unless I was dying then I would still think hard on it.