Cordyalis and THP

topic posted Sat, January 22, 2011 - 4:15 PM by  LLB
Botanical: Corydalis ambigua
Family: Papaveraceae (opium poppy) - Fumariaceae (fumitory)
Other common names: Corydalis Rhizome, Yan Hu So, Fumitory
Corydalis has been used in Traditional Chinese Medicine as a blood mover, sedative and painkiller   since the eighth century A.D. in China. Today, it is still used to relieve insomnia and abdominal and menstrual cramping.   Moreover, it is thought to protect against heart attacks and stroke, and is said to be a superior herb for increasing blood circulation, moving stagnant blood and improving heart arrhythmia.

Note:  The Chinese species of Corydalis, Corydalis ambigua and Corydalis yanhusuo, should not be confused with the North American species of Corydalis, Dicentra canadensis, which is often called Turkey Corn or Squirrel Corn. Though very similar in action, they are different and act somewhat differently.

The information presented herein by KT Botanicals is intended for educational purposes only. These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Corydalis is a low-growing perennial or winter annual that is native to the Zhejiang province of northern China, as well as Japan and Siberia and may also found in the deciduous forests, thickets and hedges of Europe. The semi-succulent plant is related to the opium-poppy and survives in harsh conditions of northeast Asia by storing most of its energy in its hard, bright-yellow tuber, and it bears a thin, erect green stem with green leaves and yellow flowers. The Corydalis genus consists of ten species in the United States and four hundred species worldwide. The North American plant produces purplish-tinged flowers and thrives in humus-rich, moist soil in partial shade, mostly in flood plains and swampy ground (Voss, 1985).  Included among the North American species of Corydalis are Dicentra canadensis, called Turkey Corn and Squirrel Corn, and Dicentra cucillaria, called Dutchman's Breeches, and they are sometimes used in a similar manner as the Asian species but do have somewhat different applications. The roots of all species are unearthed in autumn, when the plant is dormant, then dried and used in herbal medicine.  Corydalis has been used in Traditional Chinese Medicine (TCM) since at least the eighth century A.D., when it was noted in Ch'en Can-Zi's Materia Medica and recommended for invigorating the blood and alleviating menstrual and abdominal cramps, as well as the pain of hernias. Many years ago, Corydalis was also used to expel worms. Scientists have isolated twenty alkaloids, incorporating the most powerful, tetrahydropalmatine (THP), which acts as a sedative and analgesic, as well as dl-tetrahydropalmatine, corydaline, protopine, tetrahydrocoptisine, bulbocapnine, leonticine, corybulbine-3 and tetrahydrocolumbamine.

Beneficial Uses:
Corydalis is a bitter, slightly acrid and warm herb that has been used effectively as a sedative and tranquillizer.  Of the full range of alkaloids, the most powerful of these, tetrahydropalmatine (THP), has demonstrated many pharmacological actions on the central nervous system.  When properly used, Corydalis has been effective in easing palsy, trembling hands and general excitement.  It has also been employed to treat anxiety, restless leg syndrome and has been included in herbal preparations for Parkinson's disease.

As a sedative, Corydalis is said to induce sleep without adverse side effects, which is of great help to those who suffer from insomnia. The alkaloid, dl-THP, has been found to block certain receptor sites (i.e., dopamine) in the brain to cause sedation. In human clinical trials, patients with insomnia who were given dl-THP have demonstrated an improved ability to fall asleep, and there were no drug hangover symptoms, such as morning grogginess, dizziness or vertigo reported by those people taking the alkaloid extract. Corydalis is also thought to increase the sleep-inducing effect of barbiturates. The herb is said to be particularly useful for counteracting the effects of caffeine or amphetamines.

Corydalis is also considered an analgesic and antispasmodic that diminishes pain. The THP acts on the central nervous system to reduce nerve pain, and reports from Chinese researchers have noted that the herb was effective in reducing nerve pain in seventy-eight percent of the patients tested. As a painkiller, Corydalis is believed to be especially helpful in cases of dysmenorrhea (painful menstruation) and abdominal pain after childbirth. It is also said to relieve abdominal cramping and spasms (confirming the herb's historic applications in Traditional Chinese Medicine). Its painkilling effects also help to relieve headache and lumbago, as well as the pain of traumatic injury.

Recent laboratory studies have indicated that the alkaloids in Corydalis possess cardiovascular actions and may help to protect against heart attacks and strokes. The reports claimed that the THP in the herb helped to lower heart rate, and the dl-THP increased circulation and decreased both blood pressure and the stickiness of platelets in the blood, which protects against stroke. In clinical trials patients who were suffering from a specific type of heart arrhythmia (i.e., supra-ventricular premature beat or SVPB) were given dl-THP, and demonstrated significant improvement.  It is considered a fine blood tonic that stimulates and moves stagnant blood (blood stasis) and improves circulation to all areas of the body. In Traditional Chinese Medicine (TCM), Corydalis has been used for centuries to invigorate the blood, moving stagnant blood and facilitating the movement of
"Qi" - the vital energy of body fluids, bloods, moving particles, etc., throughout the body.

Corydalis may be useful in treating stomach ulcers. In clinical trials, patients suffering with stomach and intestinal ulcers or chronic inflammation of the stomach lining were given Corydalis extract. Seventy-six percent of the patients reported improved healing, and their symptoms were eased.

There are currently many additional studies being conducted for a variety of applications using Corydalis. Extracts of corydalis are said to slow the formation of cataracts associated with diabetes (but should be used under direction of physician), and it is also said to have antibacterial properties. Other research suggests action on the thyroid and adrenal cortex.

I just ordered some from here which is also where I got this cut and pasted info

I am really excited about this one and wish to learn how to extract it...
I also want to try it with Phenibut for a sleep and after working in hell anxiety reducer... I can't sleep any more...
posted by:
offline LLB
  • Re: Cordyalis and THP

    Sat, January 22, 2011 - 4:20 PM
    I've also discovered I've got case management induced high blood pressure now so this is exactly what I need.
    I am hearing of people smoking the extract which is interesting at much lower doses of about 100mg which is wonderful!
    • Re: Cordyalis and THP

      Sun, January 23, 2011 - 12:45 PM
      i tried making and extract with alcohol, under reflux for a day or so , but sadly my flask cracked and i lost it all, not sure what the best way to extract is though, if you succeed in extraction let u know ay.

      but really corydalis is pretty strong so i dont think there is any need to extract it.

      powder and take with some whiskey or something,
      • Re: Cordyalis and THP

        Sun, January 23, 2011 - 1:35 PM
        That's great to know. I'm considering working for a local headshop making legal highs lol... But really this one I think is really helpful as an alternative to painkillers and benzos that are just flooding the black market and really messing people up...
        • Re: Cordyalis and THP

          Sun, January 23, 2011 - 5:16 PM
          Oy. corydalis is just an adjunctive herb- it should be part of an overall formula, not used singly and symptomatically for insommnia. It is a warming to hot herb, and will further complicate issues down the road if it is not balanced by other cooling medicines. recipes for restless shen and deficiant yin will help you in the long term.. the folks at kt herbs have just made a huge mish mash of information of anything ever printed on corydalis. Thats one of the reasons i don't like business links- they are there to sell you something, so there is a info overwhelm to make something appear to be more usefful or have more applications than it may really have... corydalis is a nice plant person, but probably not quite what you are hoping for. If i remember correctly, persons with nephritis and other urinary issues may need to observe its effects before taking larger doses. My personal feeling is that it is most effective at mid level blood stasis levels. You have big stress long time- there will not be one 'thing' that will help you sleep- its a combined effort of the yin organs and other strategies that can help dissipate the excess toxic heat, so it doesn't accumulate- which makes one grumpy and almost unable to settle the mind down sleep. It does work on some different receptors, so i might smoke it if i were intrested, but i wouldn't make a product for head shops tho, people are not any clearer on corydalis than anything else, and some people will have not expected recreational responses- not alot, but enouph that feel unfocused, or 'stoned' in an unfamiliar way. Just my two cents.
          • Re: Cordyalis and THP

            Sun, January 23, 2011 - 5:19 PM
            ''Corydalis has been used in Traditional Chinese Medicine as a blood mover, sedative and painkiller since the eighth century A.D. in China. Today, it is still used to relieve insomnia and abdominal and menstrual cramping. Moreover, it is thought to protect against heart attacks and stroke, and is said to be a superior herb for increasing blood circulation, moving stagnant blood and improving heart arrhythmia. ''
            Salvia, (dan shen) is much better suited for these actions, and it has been proven safe for febrile conditions............
            • Re: Cordyalis and THP

              Sun, January 23, 2011 - 5:56 PM
              Why thank you kind sir! I've planned to mix it with valerian and Phenibut, it's in the mail so we shall see I suppose. My theory is that the combo of the three might give me the response I'm looking for.
              I'm very curious though about this salvia though... My stress levels are I think literally killing me, and where I know that an antianxiety med is no long term solution, currently surviving while one has no other real choices seems to be better then eating a bullet...
              Damned if you do damned if you don't... It's more perseverance these days.
              Fortunately my urinary tract is healthy same with the bladder the doctor ambushed me with a damn endoscopy... I felt so violated! Lol
              • Re: Cordyalis and THP

                Sun, January 23, 2011 - 7:27 PM
                hee hee, valerian is a warming plant too.licorice, peony poria salvia might be easy ways to augment corydalis.; You will like salvia root when you work with it. They make a patent medicine with just salvia and a tiny bit of borneol for angina / heart attacks. It is circulating to the blood, but cool, rather than hot. might i suggest you look into the An Shen Bu Xin formula for sleep help? a simple but effective short term sleep formula can be compsed of

                Polygala (Yuan zhi)
                zizyphi seed (suan zao ren)
                ammenarhea root
                poria fungus
                licorice gan cao
                peony bai shao
                dragon bone

                honeysuckle flower, licorice and poria is a great cooling tea, and in higher amounts, honeysuckle flower has a nice sedating effect, and cools the blood.

                a yin blend for the kidneys, liver and lung would be good ways to start replentishing depleted yin, and that will cool the agitated liver heat and wind that produce the restless spirit that is hard to sleep.
                rehmannia 8 (kidney)
                relaxed wanderer plus, or maybe better, tian ma gou teng wan (liver)
                a general lung formula that includes mulberry bark and adenophora (lung)

                no one ever pays attention to these.>:>:>:>:> ion form liquid suspension of magnesium and calcium. and molybydenum. If you get wateroz brand magnesium concentrate, and it can sock you like a real good chemical sedative. they also make a lithium that isn't hard on the body.anyways, thats my 4 and one half cents.;
                • Re: Cordyalis and THP

                  Sun, January 23, 2011 - 8:45 PM
                  Hmmmm you got a good source for the salvia?
                  • This is the maximum depth. Additional responses will not be threaded.

                    Re: Cordyalis and THP

                    Sun, January 23, 2011 - 9:02 PM
                    yeah. my friend kevin at i think he has a nice dry extract as well as the whole herb. hes got lots of great medicines.
                    • Re: Cordyalis and THP

                      Mon, January 24, 2011 - 8:30 AM
                      I will check it out...
                      Tryptophan helped a little last night. I still woke up several times but was able to get back to sleep faster. The waking up and falling asleep pattern has really enhanced my dreams... Last night I dreamed I had a son and woke up thinking about agape...
                      • Re: Cordyalis and THP

                        Wed, January 26, 2011 - 7:34 PM
                        hey does the bleeding heart help at all? i've got a nice strong valerian root tincture at home, also elephant's head (can't remember the latin name...) & a bit of monotropa tincture still... sorry your so stressed friend...
                        • Re: Cordyalis and THP

                          Thu, January 27, 2011 - 9:37 AM
                          The bleeding heart has not really done much for me. I've started taking tryptophan which has gotten rid of the depression that's resulted from way to much stress and anxiety over the year, but it has not helped with sleep or anxiety and stress reduction/relaxation. I've basically had to push myself to far for to long and indent see any end of that dynamic currently.
                          Rosea rohdiolia and holy basil with shizandra and ashwaganda worked for a while in a comPlex but no longer... No sleep due to waking up with racing thoughts makes it worse.
                          However last night night tryptophan and a new GABA antagonist called Phenibut that's a nutritional supplement was able to provide a deeper sleep then usual with still some waking but quickly going back to sleep. With luck and rotating intKe schedul I will he able to work with that one combined with cordyalis or valerian extract to chill
                          The hell out...
                          I surmise that Phenibuts effects will be greatly enhanced by valerian root.

Recent topics in "Flint's Herbal Medicine"

Topic Author Replies Last Post
Cordyceps Chinensis Flint 中 0 January 23, 2016
Saffron Flint 中 0 January 23, 2016
Back in Zee Zaddle again! Flint 中 0 April 19, 2014
Just What in the Heck is Healing? Flint 中 1 August 13, 2013